It can be subdivided into three elements. In each case, there can be progression to the next stage, but most people don't progress there. The stages are:
- Steatosis (fatty liver) - simple fat accumulation within the hepatocytes (note, not the adipocytes). It is generally believed to be a harmless condition.
- Non-alcoholic steatohepatitis (NASH) - fatty accumulation as above plus associated surrounding inflammation and hepatocyte necrosis. Eventually, this process can progress to include fibrosis, which leads smoothly towards...
- Cirrhosis - obviously not limited to the NAFLD spectrum (it can be caused, and far more commonly is, by other things), but a definite potential outcome of long-standing NASH.
Although some authorities prefer to limit the definition of NAFLD to that caused by insulin resistance, most centres recognise insulin resistance as only the most common cause of NAFLD. The list of other causes is extensive, and includes drugs, toxins, malnutrition, total parenteral malnutrition, dyslipidaemias, etc.
Diagnosis is primarily one of exclusion, but is suggested by:
- unexplained raised transaminases (AST, ALT) - things like viral hepatitis must be excluded
- in associated with an enlarged fatty liver - this can be presumptively shown on ultrasound (hyperechoic/bright liver), CT or even MRI. Only a liver biopsy is definitive, but this is usually not necessary.
- if a significant alcohol history can be excluded
Treatment is again controversial, and much more research is required before any sort of consensus can be reached. Currently, if the cause is insulin resistance, many authorities recommend treating the 'metabolic syndrome' aspects of the condition; specifically, weight loss, and (diabetic) drugs that reduce insulin resistance (metformin and the thiazolidinediones) are promising.
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ReplyDeleteMany people who are overweight or who have diabetes, prediabetes, or high cholesterol may also have liver damage without knowing it. Nonalcoholic steatohepatitis (NASH) is a liver disease that occurs when a buildup of fat in the liver causes irritation (inflammation) and damage that may interfere with how the liver works. Many people with NASH feel fine and do not even know they have the condition.
ReplyDeleteIf you have been told that you have or may have either NASH or a fatty liver, and diet and exercise haven’t worked, you may want to consider participation in the VIA clinical research study.
What is the purpose of the VIA clinical research study?
The VIA study is evaluating whether a once-daily, oral investigational medication called volixibat, is tolerable, safe, and effective in reducing liver damage in people with NASH. The study will evaluate the effects (if any) of three different doses of volixibat in patients with NASH.
For more details click here